Itraconazole has the following interaction information: Abemaciclib. Itraconazole is predicted to increase the exposure to abemaciclib. Manufacturer advises avoid or adjust abemaciclib dose. Itraconazole is predicted to erection the exposure to acalabrutinib. Manufacturer advises avoid. Itraconazole potentially increases the anticoagulant effect of acenocoumarol.